VEGF Gene Polymorphism And Study On Genetic Susceptibility Of Neuropsychiatric Lupus

Abstract

Abstract Background: Vascular endothelial growth factor ( VEGF ) plays an important role in the pathogenesis of neuropsychiatric lupus ( NPSLE ), This study was designed for analysis of the relationship between single nucleotide polymorphisms of VEGF gene rs699947, rs10434, rs833070 and genetic susceptibility to NPSLE. Methods: A total of 82 patients diagnosed as NPSLE and without other autoimmune diseases were selected as the NPSLE group (positive group). Non-NPSLE group (positive control group) 166 patients with systemic lupus erythematosus without psychiatric symptoms. According to the principle of age matching with the positive control group, 150 healthy subjects were randomly selectedas the healthy control group (negative control group). The allele and genotype of three SNP loci and the correlation between NPSLE and non-NPSLE were analyzed. Results: 1. The genotype frequencies of GG, GA and AA genotypesat rs10434 locus were statistically significant in NPSLE group, non-NPSLE group and negative control group (P < 0.05). 2. The genotype and allele frequencies of rs699947 and rs833070 loci werenot statistically significant in the NPSLE group, non-NPSLE group and negative control group (P > 0.05). 3. rs10434 locus GG genotype and G gene as reference, A allele, mutant heterozygous model GA, dominant model (GA+AA ) were associated with therisk of NPSLE (P < 0.05). Conclusion: We found that VEGF rs10434 A allele, mutant heterozygous model GA, dominant model GA+AA can increase the risk of NPSLE. A allele and dominant model GA+AA can increase the risk of non-NPSLE. There was no significant correlation between rs699947 and rs833070 polymorphism and the risk of NPSLE and non-NPSLE.