Diagnostic yield of Induced sputum and Bronchoalveolar Lavage in Suspected Pulmonary Tuberculosis

Author:

Musso Maria1,Gualano Gina1,Mencarini Paola1,Mastrobattista Annelisa1,Licata Maria Angela1,Pareo Carlo1,Cerva Carlotta1,Mosti Silvia1,Bari Virginia Di1,Libertone Raffaella1,Nisii Carla1,Cannas Angela1,Navarra Assunta1,Goletti Delia1,Palmieri Fabrizio1

Affiliation:

1. National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS

Abstract

Abstract

Aim of this study was to compare the diagnostic yield of induced sputum (IS) and bronchoalveolar lavage (BAL) in patients with suspected pulmonary tuberculosis (PTB) and negative sputum smears. We enrolled 215 patients who underwent both IS and BAL after two negative spontaneous sputum samples. PTB was confirmed by culture or molecular test in 26 patients (12.1%). IS detected 10 cases (38.5%) of all PTB, while BAL detected 22 cases (84.6%) of all PTB. IS had a sensitivity of 38.46% and a specificity of 100%, while BAL had a sensitivity of 84.62% and a specificity of 100%. BAL had a higher diagnostic yield than IS and was useful for ruling out alternative diagnoses. According to our experience FBS execution is mandatory in case of strong TB suspicion and sputum smear negative patients, especially in a low TB prevalence country. Moreover, it consents testing microorganism sensitivity and assessing possible alternative diagnosis with similar clinical presentation. The choice of the best diagnostic method may depend on the clinical context and the availability of resources.

Publisher

Springer Science and Business Media LLC

Reference32 articles.

1. Global tuberculosis report 2023. Geneva, World Health Organization. : 2023. Licence: CC BY-NC-SA 3.0 IGO (available at [URL], accessed 03/05/24).

2. I casi di Tubercolosi in Italia - Periodo 2009–2021. Ministero della Salute. 2023 (available athttps://www.salute.gov.it/portale/documentazione/p6_2_2_1.jsp?lingua=italiano&id=3387).

3. Diagnosis of Tuberculosis in Adults and Children;Lewinsohn DM;C lin Infect Dis,2017

4. Diagnostic yield of sputum microbiological analysis in the diagnosis of pulmonary tuberculosis in a period of 10 years. A Tavares e Castro, Mendes M, Freitas S, Roxo PC. Rev Port Pneumol (2006). 2015 Jul-Aug;21(4):185 – 91.

5. Diagnostic value of bronchoalveolar lavage and bronchial washing in sputum-scarce or smear-negative cases with suspected pulmonary tuberculosis: a randomized study;Kim YW;Clin Microbiol Infect,2020

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