Risk factors of thrombosis in Chinese subjects with myelodysplastic syndrome

Abstract

Abstract Background: Myelodysplastic syndrome(MDS)) is a common hematological malignancy. Patients with myelodysplastic syndrome combined with thrombosis have been encounter in clinical practice. However, the incidence of thrombosis and the risk factors of thrombosis related to Chinese MDS patients are not fully understood. Materials and Methods: Clinical data from a total of 133 Chinese MDS patients with were studied and analyzed. Results:The study population consisted of 133 patients with primary diagnosis of MDS，69(52%) males and 64 (48%) females ,range 47–81 years. In terms of gender ratio (P = 0.68), age (P = 0.82), white blood cell count (P = 0.87), hemoglobin (P = 0.78), platelet count (P = 0.83), and IPSS-R risk stratification, there was no significant difference between the two groups. PAI-1 4G4G showed significant differences between the two groups(P=0.0009), suggesting a thrombotic risk factor. There was significant difference between the two groups in SF3B1 mutations. In ASXL1(P = 0 .6)、BCOR(P = 0 .66)、EZH2(P = 0 .66) and SRSF2(P = 0 .6) there were no statistically significant differences between the two groups.In either group, STAG2, U2AF1 and ZRSR2 were not mutated, so no statistical analysis could be conducted. Conclusion: The incidence of venous thrombosis in primary MDS in China is 5.26%. SF3B1 mutations and PAI-1 gene 4G4G are associated with thrombotic events in Chinese MDS patients.