Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cell Implantation Versus Microdrilling combined with High Tibial Osteotomy for Cartilage Regeneration

Author:

Jung Se-Han1,Nam Bum-Joon1,Choi Chong-Hyuk2,Kim Sungjun1,Jung Min2,Chung Kwangho3,Park Jisoo1,Jung Youngsu2,Kim Sung-Hwan1

Affiliation:

1. Gangnam Severance Hospital

2. Severance Hospital

3. Yongin Severance Hospital, Yonsei University College of Medicine

Abstract

Abstract This study compared cartilage regeneration outcomes in knee osteoarthritis (OA) using allogeneic human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) implantation and microdrilling with high tibial osteotomy (HTO). Fifty-four patients (60 knees) were included: 24 in the hUCB-MSC group and 30 in the microdrilling group. Both groups showed significant improvements in pain and functional scores at 6, 12, and 24 months compared to baseline. At 24 months, hUCB-MSC group had significantly improved scores. Arthroscopic assessment at 12 months revealed better cartilage healing in the hUCB-MSC group. In subgroup analysis, hUCB-MSC showed superior results for anterior lesions. Both treatments demonstrated effectiveness for medial OA. However, hUCB-MSC implantation had better patient-reported outcomes and cartilage regeneration than microdrilling. The study suggests promising approaches for cartilage restoration in large knee defects due to OA.

Publisher

Research Square Platform LLC

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