Abstract
Background
Nocturia, a common condition marked by frequent nighttime urination, significantly impacts quality of life. This study explores the association of metabolic index METS-IR ( Metabolic Score for Insulin Resistance) and ABSI (A Body Shape Index) with nocturia, utilizing data from the National Health and Nutrition Examination Survey (NHANES).
Methods
A cross-sectional analysis of NHANES data from 2005–2020 was performed. The associations between METS-IR, ABSI, and nocturia were evaluated using multivariable logistic regression, accounting for demographic characteristics, chronic diseases, and lifestyle factors. Generalized additive models and smoothing spline techniques described the relationship dynamics.
Results
Of the 16,450 participants, significant associations were observed between nocturia and both METS-IR (OR: 1.01, 95% CI: 1.01–1.02, p < 0.0001) and ABSI (OR: 1.03, 95% CI: 1.02–1.04, p < 0.0001). Higher quartiles of METS-IR and ABSI were associated with increased risks (OR for METS-IR Q4: 1.53, 95% CI: 1.36–1.71; OR for ABSI Q4: 1.38, 95% CI: 1.23–1.55). Stratified analyses indicated consistent patterns across demographics, with marital status impacting the ABSI-nocturia relationship. Nonlinear modeling revealed a threshold effect for ABSI at 76.2.
Conclusion
Increases in METS-IR and ABSI are closely linked with a higher prevalence of nocturia, indicating that these metabolic index can be used in clinical assessments to evaluate the risk of nocturia and support the formulation of preventive and therapeutic strategies.