Effectiveness of defocus lenses in youth vision control Running Title: a meta-analysis

Abstract

Abstract Purpose: To systematically evaluate the effectiveness of defocused lenses in the control of adolescent visual acuity. Methods: The Cochrane library, Web of science, PubMed, Proquest and Chinese biomedical literature databases Wanfang, Vipu and CNKI were used to search for relevant literatures on the controlled trial of defocusing lenses in adolescent vision control from self-built databases to June 2023. According to the inclusion and exclusion criteria, 5 studies were selected for meta-analysis. RevMan 5.3 software was used to analyze the included literatures and explore the heterogeneity of each study. Results: 5 controlled trials involving 947 subjects were finally included. meta-analysis showed that defocus lenses slowed the increase in myopic refraction [OR: 0.21, 95CI% (0.09, 0.33), p=0.0008], reduced refraction levels [OR:-0.30, 95CI% (-0.58,-0.01), p=0.04] , reduced axial length [OR: 0.49, 95CI% (0.31, 0.67), P<0.00001], all of the above differences were statistically significant. The funnel plots for each study suggested that the scatter was essentially symmetrical and in to a funnel-shaped distribution, so the funnel plots suggested no publication bias. Conclusion: Defocus lenses used in youth vision control are effective in slowing down the increase in myopic refraction and reducing refraction levels and axial length.