The Cellular Origin of the Pulmonary Pericyte

Author:

Rottier Robbert1ORCID,Sree Isabel1,Boers Ruben2ORCID,Boers Joachim2,Tan Beatrice1ORCID,Munck Anne Boerema-de1,Kempen Marjon Buscop-van1,IJcken Wilfred van2ORCID,Schnater J. Marco1ORCID,Wijnen René3,Gribnau Joost4ORCID

Affiliation:

1. Erasmus Medical Center

2. Erasmus University Medical Center

3. Department of Pediatric Surgery, Erasmus University Medical Centre Rotterdam

4. Erasmus MC

Abstract

Abstract

Emerging evidence suggests pericytes play a significant role in various lung diseases. However, characterizing pericytes remains challenging, impeding our understanding of their role in lung development and disease. Using single-cell RNA sequencing and DCM-time machine technology, we tracked the development of mouse pulmonary pericytes. Our study revealed the differentiation of perivascular progenitors into pericytes and vascular smooth muscle cells. Temporal analysis uncovered dynamic gene expression profiles during pericyte differentiation, highlighting pathways crucial for pulmonary vascular development. Further analysis showed intricate signaling interactions between pericyte progenitors and mature pericytes, and we validated Mcam as a bona fide pulmonary pericyte marker. These findings challenge conventional views on pericyte origin and underscore the importance of accurate pericyte identification in developmental and disease contexts. Overall, this study enhances our understanding of pulmonary pericyte ontogeny and differentiation, offering insights into their potential as therapeutic targets in pericyte-associated lung diseases.

Publisher

Springer Science and Business Media LLC

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