Resorbable Barrier Polymers for Flexible Bioelectronics-Reference-Cited by-同舟云学术

Resorbable Barrier Polymers for Flexible Bioelectronics

Published:2023-05-17 Issue: Volume: Page:
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Author:

McDonald Samantha¹^ORCID,Yang Quansan²,Hsu Yen-Hao¹,Nikam Shantanu¹,Hu Ziying²,Wang Zilu³,Asheghali Darya⁴,Yen Tiffany¹,Dobrynin Andrey⁵,Rogers John²^ORCID,Becker Matthew¹

Affiliation:

1. Duke University

2. Northwestern University

3. University of North Carolina Chapel Hill

4. The University of Georgia

5. University of North Carolina at Chapel Hill

Abstract

Abstract Resorbable, implantable bioelectronic devices are emerging as powerful tools to reliably monitor critical physiological parameters in real time over extended periods. While degradable magnesium-based electronics have pioneered this effort, relatively short functional lifetimes have slowed clinical translation. Barrier films that are both flexible and resorbable over predictable timelines would enable tunability in device lifetime and expand the viability of these devices. Herein, we present a library of stereocontrolled succinate-based copolyesters which leverage copolymer composition and processing method to afford tunability over thermomechanical, crystalline, and barrier properties. One copolymer composition within this library has extended the functional lifetime of transient bioelectronic prototypes in vivo over existing systems by several weeks – representing a considerable step towards translational devices.

Publisher

Research Square Platform LLC

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