Affiliation:
1. Jilin University
2. The First Hospital of Jilin University
Abstract
Abstract
Background: This study aims to investigate the bidirectional causal relationship between systemic cytokines and periodontitis.
Methods: We conducted a bidirectional two-sample Mendelian randomization study of the relationship between systemic cytokines and periodontitis using inverse variance weighted, weighted median and MR-Egger regression. The genome-wide association study data included information on 41 cytokines in 8293 individuals and periodontitis in 456,348individuals.
Results: Increased systemic granulocyte colony-stimulating factor (G-CSF) levels were found to be a risk factor for periodontitis (Odds ratio =1.564, 95% confidence interval = 1.137-2.150, P = 0.006). Heterogeneity and horizontal pleiotropy were not detected.
Conclusions: Our findings suggest that G-CSF may have an essential role in the progression of periodontitis.
Publisher
Research Square Platform LLC
Reference34 articles.
1. Association between Periodontitis and Carotid Artery Calcification: A Systematic Review and Meta-Analysis;Wang W;Biomed Res Int,2021
2. The impact of periodontitis on vascular endothelial dysfunction;Li Q;Front Cell Infect Microbiol,2022
3. Diabetes mellitus and periodontal diseases;Mealey BL;J Periodontol,2006
4. The Gum-Gut Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances;Byrd KM;Front Immunol,2021
5. Aggressive and acute periodontal diseases;Albandar JM;Periodontol 2000,2014