Effects of temperature and humidity on cerebrovascular disease hospitalization in a super- aging society

Abstract

Abstract Weather conditions influence the incidence of cardiovascular disease. However, few studies shown the association of weather temperature and humidity with cerebrovascular disease hospitalizations in a super-aging society. We included 606,807 consecutive patients with cerebrovascular disease admitted to Japanese acute-care hospitals between 2015 and 2019. The primary outcome was the number of cerebrovascular disease hospitalizations per day. Multilevel mixed-effects linear regression models were used to estimate the association of mean temperature and humidity, 1 day before hospital admission, with cerebrovascular disease hospitalizations, after adjusting for air pollution, hospital, and patient demographics. Lower mean temperatures and humidity < 70% or humidity ≧ 70% are associated with an increased incidence of cerebrovascular disease hospitalization (coefficient, -1.442 [-1.473 to -1.411] per ℃, p < 0.001, coefficient, -0.084 [-0.112 to -0.056] per%, p < 0.001, and coefficient, 0.136 [0.103 to 0.168] per %, p < 0.001, respectively). Lower mean temperatures and extremely low or high humidity are associated with an increased incidence of cerebrovascular disease hospitalization in the super-aging society.