N-nitrosomorpholine-induced Oncocytic Transformation in Rat Endocrine Organs

Author:

GEZER Emre1,ÖZER Cüneyt2,ŞİMŞEK Turgay2,BAYRAK Büşra YAPRAK2,TURAN Gupse2,ÇETİNARSLAN Berrin2,SELEK Alev2,CANTÜRK Zeynep2,SÖZEN Mehmet2,KÖKSALAN Damla2

Affiliation:

1. Darica Farabi Training and Research Hospital

2. Kocaeli University

Abstract

Abstract Background N-nitrosomorpholine (NMO) is one of the most common N-nitroso compounds. An oncocytic transformation has been demonstrated in renal tubules of NMO-treated rats. In our study, we aimed to investigate the potential transformation of oncocytic cells in 6 endocrine organs, i.e., thyroid, adrenal and pituitary glands, pancreas, testis, and bone, of NMO-exposed rats.Methods Thirty male rats were born and raised. Fifteen of them were given a single dose of 320 mg NMO per kg body weight, dissolved in drinking water, by a gavage tube. At the end of 52 weeks, the animals in both series were sacrificed. Right after the sacrifice, 6 different endocrine organs (hypophysis, thyroid, pancreas, adrenal gland, bone [femur], and testicles) of each animal were excised.Results There was no evidence of oncocytic cell development in the control group. In contrast, oncocytes were observed in 8 out of 13 NMO-treated rats: 2 in the adrenal sections, 1 in the thyroid sections, 3 in the pituitary sections, and 2 in the pancreas sections. The cells in the testicle and bone sections were completely normal.Conclusions We showed that NMO induced an oncocytic change in pancreas, thyroid, pituitary, and adrenal glands. To date, no identified specific environmental risk factors that lead to an oncocytic transformation in endocrine glands have been reported previously. Given the increasing prevalence of endocrine-disrupting chemicals in the environment, personal care products, manufactured goods and food sources, there is a need to advance our understanding of the pathological mechanisms underlying oncocytosis in endocrine organs.

Publisher

Research Square Platform LLC

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