Birth outcomes of infants born to mothers with alopecia areata: A nationwide population-based study in Korea

Author:

Shin Jung-Won1,Kang Taeuk2,Swan Heather3,Paik Kyungho1,Huh Chang-Hun1,Kim Hyun Jung3

Affiliation:

1. Seoul National University Bundang Hospital

2. National Health Insurance Service

3. Korea University College of Medicine

Abstract

Abstract

Data on pregnancy outcomes in patients with alopecia areata (AA) are limited. The aim of this study is to determine the association between maternal AA and risk of adverse birth outcomes in children, we conducted a retrospective cohort study on 45,328 children born to mothers with AA and 4,703,253 controls born to mothers without AA using the Korean National Health Insurance Claims database from 2002 to 2016. Multivariate logistic regression analyses were performed to evaluate the association between maternal AA and the birth outcomes of their children. Infants born to mothers with AA exhibited a significantly higher risk for preterm birth (odds ratio [OR], 1.39; adjusted OR [aOR], 1.14), low birth weight (OR, 1.36; aOR, 1.15), and cesarean section birth (OR, 1.24; aOR, 1.10)than controls. In addition, the risk of congenital malformations was also significantly higher in infants born to mothers with AA (OR, 1.19; aOR, 1.12), especially for malformations of the urinary (OR, 1.33; aOR, 1.18), circulatory (OR, 1.28; aOR, 1.11), nervous (OR, 1.26; aOR, 1.15), and musculoskeletal (OR, 1.19; aOR, 1.13) systems, than controls. Maternal AA is associated with an increased risk of adverse birth outcomes in infants.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3