Diagnostic significance and utility of circulating redox biomarkers in patients with gastric cancer

Abstract

Abstract The aim of our study was to evaluate the redox status, antioxidant barrier as well oxidative damages in gastric cancer patients. We are also the first to assess the diagnostic utility of redox parameters in GC patients in respect to histopathological parameters. 50 patients with gastric cancer and 50 healthy controls matched for sex and age were included in the study. Antioxidant barrier, redox status and oxidative damage products were measured in serum/plasma samples using colorimetric or spectrophotometric method. The activity of SOD (p < 0.05) was significantly higher whereas the activity of CAT (p < 0.0001), GPx (p < 0.0001), GR (p < 0.0001) and GSH (p < 0.05) was considerably lower in GC patients compared to the control group. Levels of TOS (p < 0.0001), OSI (p < 0.0001), AOPP (p < 0.0001), IMA (p < 0.01), LOOH (p < 0.0001), 8-Iso-P (p < 0.0001) and DNA/RNA (p < 0.0001) were significantly higher, and the levels of TAC (p < 0.0001) and total thiols (p < 0.0001) were considerably lower in GC patients compared to the healthy control. Some redox parameters are characterised by high AUC value in differentiation GC patients according to histopathological parameters. Gastric cancer is strongly linked to systemic redox imbalance as well as increased oxidative damage to proteins, lipids and DNA. Redox biomarkers can be potential diagnostic indicators of gastric cancer advancement.