Amiodarone Induced Myxedema Coma: A Systematic Review of Case Reports

Abstract

AbstractObjective The current systematic review examined whether elderly patients who received amiodarone were at risk for developing myxedema coma. Methods The Cochrane guidelines were used for a systematic review of Medline (PubMed), Science Direct, CINAHL Cochrane database, and Google Scholar for case reports on the Amiodarone-induced myxedema coma. Results A total of 12 case reports were found to meet the determined inclusion criteria. Patients who received amiodarone highly risk of developing myxedema coma. Case reports showed that patients received 100–200 mg of amiodarone orally and developed bradycardia and hypothermia with elevation in thyroid stimulating hormone. Most patients were treated with levothyroxine and hydrocortisone medication upon diagnosis. Conclusion The various possible causes of Myxedema coma make diagnosis difficult. Through clinical symptoms and serum TSH, the diagnosis could be confirmed. Amiodarone-induced Myxedema coma was successfully treated with levothyroxine and glucocorticoids.