The relationship between Bisphenols exposure and intestinal flora: a systematic review and meta-analysis

Abstract

Abstract A growing number of studies have indicate that Bisphenols (BPs) have an effect on gut microbial community, including alter gut microbial diversity and composition. Due to limited sample size and some varied results, a review is needed to add credibility to the conclusion of BPs influence on gut microbial community. Literature search was implemented based on PubMed,Wed of Science, Science Direct, SinoMed, CNKI database from inception date to February 24,2022. Nineteen eligible articles (BPs exposure on rodent animal experiment studies) were included to our review and all literature’s references were traced back. Meta analysis were conducted to synthesis 5 alpha diversity index(observed species, chao, ace, Shannon, Simpson index), narrative synthesis approach was selected to synthesis composition of gut microbial in BPs group. Results suggest Simpson index significantly increase after BPs intervention. In subgroup analysis, Simpson significantly increase in low dose group( dosage ≦ 0.20mg/kg), observed species significantly decrease in long term group(duration > 5 weeks), chao index decrease in short term group and increase in long term group, chao and Shannon decrease in intestine sample group. To conclude, BPs exposure may decrease the abundance and diversity of gut microbial especially probiotic.