The evaluation of nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients: study protocol for a randomized controlled trial-Reference-Cited by-同舟云学术

The evaluation of nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients: study protocol for a randomized controlled trial

Published:2023-08-03 Issue: Volume: Page:
ISSN:
Container-title:
language:
Short-container-title:

Author:

Golmohammadi Ashkan¹,Hosseinikia Mahboobe¹,Sadeghi Mohammad Kazem¹,Golampur Dariush¹,Hosseinzadeh Zahra¹,Panahande SeyedBahman¹^ORCID

Affiliation:

1. Yasuj University of Medical Sciences

Abstract

Abstract Background and objectives Rheumatoid arthritis (RA) is a chronic disease with the global prevalence rate of 1%. Some RA patients constantly complain about adverse effects they are experiencing after consumption of nightshades. These plants contain Solanine which can cause damage to the bones and joints. Considering the literature, no RCT has been conducted about nightshade effects on RA patients, this study aims to assess the impact of a nightshade elimination diet (NED) on inflammatory and rheumatologic markers of rheumatoid arthritis patients for the first time. Methods A single-blinded controlled trial will be conducted to evaluate the effect of a NED on 36 participants for 8 weeks (2 months). The patients will be equally divided in two intervention and placebo groups. Both groups will receive general anti-inflammatory dietary recommendations and the Intervention group will be undergone a NED during the study. Clinical symptoms will be determined using questionnaires. Moreover, blood samples will be collected from participants to measure desired indicators. Discussion To the best of our knowledge, this study will be the first RCT investigating the effect of NED on inflammatory and rheumatologic markers of rheumatoid arthritis patients. The possible results of this study could be useful for nutritionists and physicians in managing RA patients. Trial registration Iranian Registry of Clinical Trials (irct.ir) IRCT20230220057465N1. Registered on 8 April 2023.

Publisher

Research Square Platform LLC

Reference24 articles.

1. Mazzucca CB, Scotti L, Cappellano G, Barone-Adesi F, Chiocchetti A. Nutrition and Rheumatoid Arthritis Onset: A Prospective Analysis Using the UK Biobank. Nutrients [Internet]. 2022 Jan [cited 2023 Mar 23];14(8):1554. Available from: https://www.mdpi.com/2072-6643/14/8/1554.

2. Jang S, Kwon EJ, Lee JJ. Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells. Int J Mol Sci [Internet]. 2022 Jan [cited 2023 May 7];23(2):905. Available from: https://www.mdpi.com/1422-0067/23/2/905.

3. Lin YJ, Anzaghe M, Schülke S. Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis. Cells [Internet]. 2020 Apr 3 [cited 2023 Mar 26];9(4):880. Available from: https://www.mdpi.com/2073-4409/9/4/880.

4. van der Woude D, van der Helm AHM. Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis. Best Pract Res Clin Rheumatol [Internet]. 2018 Apr [cited 2023 Mar 24];32(2):174–87. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1521694218300688.

5. Design of an. anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis - ScienceDirect [Internet]. [cited 2023 May 7]. Available from: https://www.sciencedirect.com/science/article/pii/S2451865420300089.