Influencing factors of incision healing in HIV positive patients with giant cell tumor of long bone in extremities

Abstract

Abstract Objective To evaluate the risk factors that affect wound healing after surgery of giant cell tumor in patients with human immunodeficiency virus (HIV). Methods 20 patients of giant cell tumor with HIV were recruited from June 2018 to June 2022, once diagnosed, 20 patients were receive timely HAART (Highly Active Antiretroviral Therapy) with China's first choice of national free HAART drug containing tenofovir disoproxil fumarate, lamivudine and efavirenz (TDF + 3TC + EFV, ). and 20 patients of giant cell tumor without HIV were enrolled as control at same time. All patients were underwent the same surgical method. Observe the incidence of infection at the surgical site and risk factors that affect wound healing were evaluated. Results The incidence of poor outcome of wound healing in HIV-positive group was higher than HIV-negative group (p < 0.05), but there was no significant difference in infection of the wound between two groups (p > 0.05). Multivariable regression analysis demonstrated that CD4 + T-lymphocyte count and clinical categories of HIV were independent risk factors for postoperative wound healing (p < 0.05), while age, gender, operation time,albumin,hemoglobin and combined disease, were not (p > 0.05). Conclusion The wound can be healed normally in most of HIV-positive patients with giant cell tumor, and the outcome of postoperative wound healing was significantly associated with CD4 + T-lymphocyte coun and HIV clinical category. At the same time, we recommended that reasonable perioperative adjuvant treatments, including nutritional support and immunomodulators, and anti-retroviral drugs should be used.