Abstract
Abstract
Zoonotic viruses, such as coronaviruses, the Ebola virus, the Zika virus, Nipah, Laasa, and rabies, can be transmitted from animals to humans (1). There is a need to develop inhibitors because they can potentially prevent or treat viral infections in humans and animals (2). Metadichol® is a nanoemulsion of long-chain alcohols that is a potent inhibitor of viruses. We present results of in vitro assays showing that it inhibits Laasa, rabies, and Nipah viruses at concentrations of 0.8 to 2.6 µg/ml. It is likely that the binding of metadichol to VDR ( vitamin D receptor) leads to regulation of c-MYC (MYC Proto-Oncogene, BHLH Transcription Factor (which controls expression of SP1(SP1 transcription factor), which is the key step to controlling the viral replication gene GSPT1(G1 To S Phase Transition 1). Since metadichol is commercially available and nontoxic, with an LD50 of more than 5000 mg/kg in rats, it could be useful in the treatment of such zoonotic diseases.
Publisher
Research Square Platform LLC
Reference38 articles.
1. https://link.springer.com/article/10.1007/s00232-020-00136-z.
2. https://link.springer.com/article/10.1007/s11684-017-0589-5.
3. https://www.who.int/news-room/fact-sheets/detail/zoonoses.
4. https://www.cdc.gov/onehealth/basics/zoonotic-diseases.html.
5. https://www.who.int/news-room/fact-sheets/detail/zoonoses.