Tongue Necrosis Secondary to Giant Cell Arteritis, Successfully Treated with Tocilizumab: A Case Report-Reference-Cited by-同舟云学术

Tongue Necrosis Secondary to Giant Cell Arteritis, Successfully Treated with Tocilizumab: A Case Report

Published:2023-03-23 Issue: Volume: Page:
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Author:

Cho Young Min¹,Khoury Lara El¹,Paramo Jonathan¹,Horowitz Diane Michelle¹,Li Jian Yi²,Kello Nina¹

Affiliation:

1. Department of Rheumatology, Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Long Island, NY, USA

2. Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/North

Abstract

Abstract Background: Giant Cell Arteritis (GCA) is a large vessel vasculitis that most commonly presents with headache, scalp tenderness, jaw claudication, and vision changes. Various other, less common, manifestations have been reported in the literature such as scalp and tongue necrosis. Though most patients respond to corticosteroids, some cases of GCA are refractory to the high doses of corticosteroids. Case presentation: We present a 73-year-old female with GCA refractory to corticosteroids presenting with tongue necrosis. This patient significantly improved with a dose of tocilizumab, an IL-6 inhibitor. Conclusion: To the best of our knowledge, this is the first case report of a patient with refractory GCA presenting with tongue necrosis that had rapid improvement with tocilizumab.

Publisher

Research Square Platform LLC

Reference31 articles.

1. 1. Salvarani C, Pipitone N, Versari A, Hunder GG. Clinical features of polymyalgia rheumatica and giant cell arteritis. Nature Reviews Rheumatology. 2012;8(9):509 − 21.

2. 2. DeBord LC, Chiu I, Liou NE. Delayed diagnosis of giant cell arteritis in the setting of isolated lingual necrosis. Clinical Medicine Insights: Case Reports. 2019;12:1179547619857690.

3. 3. Dotiwala AK, Samra NS. Anatomy, head and neck, tongue. 2018.

4. 4. Rockey JG, Anand R. Tongue necrosis secondary to temporal arteritis: a case report and literature review. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002;94(4):471-3.

5. 5. Burg LC, Schmidt WA, Brossart P, Reinking KI, Schützeichel FM, Finger RP, et al. A 78-year-old female with severe tongue pain: benefit of modern ultrasound. BMC Medical Imaging. 2021;21(1):1–7.