Association between Urine Parabens and Liver Function in US Adolescents: A cross-sectional study based on NHANES 2007–2016

Abstract

Abstract Paraben esters are commonly used as preservatives in cosmetics, personal hygiene products, food and drugs. However, there is a lack of evidence regarding the impact of exposure to Paraben esters on adolescent liver function. We analyzed data from the 2007–2016 National Health and Nutrition Examination Survey (NHANES). Finally, 1845 adolescents aged 12 to 19 were selected as a random sample. Analysis of the Effect of Urinary Parabens on Liver Function Indexes Using Weighted Linear Regression.Then, we applied the weighted quantile sum (WQS) analysis and the Bayesian kernel machine regression (BKMR) to examine the associations between parabens and liver function indicators. Based on the results from three different models, four parabens and their total were negatively associated with ALB and ALP, and positively associated with TBIL. Moreover, among the parabens, butyl paraben and propyl paraben had the highest weights.Overall, our results indicate that parabens are significantly but weakly associated with changes in liver function in US adolescents. Further research is needed to explore these relationships.