New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides-Reference-Cited by-同舟云学术

New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides

Published:2023-11-21 Issue: Volume: Page:
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Author:

Chemutai Winnie Sum¹,Gonkhom Didsanutda²,Ibrahim Mahmoud A. A.³,Stadler Marc⁴^ORCID,Ebada Sherif S.⁵

Affiliation:

1. Helmholtz-Zentrum für Infektionsforschung GmbH: Helmholtz-Zentrum fur Infektionsforschung GmbH

2. Mae Fah Luang University

3. Minia University Faculty of Science

4. Helmholtz Zentrum für Infektionsforschung

5. Ain Shams University

Abstract

Abstract Preparative high performance liquid chromatography (HPLC) purification of the ethyl acetate extracts derived from dried basidiomes of the European mushroom Hericium coralloides led to the identification of two previously undescribed isoindolinone derivatives named corallocins D and E (1–2). The structures of the compounds were elucidated based on HR-ESIMS (high-resolution electron spray ionization mass spectroscopy), interpretation of 1D and 2D NMR spectra, circular dichroism (CD) experiments, and comparisons with published and theoretical data. The metabolites were tested for their cytotoxic and antimicrobial effects in vitro where weak to moderate biological effects were observed against HeLa cells (KB 3.1), Mucor hiemalis and Bacillus subtilis.

Publisher

Research Square Platform LLC

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