Adipocyte ZAG improves obesity-triggered insulin resistance by reshaping macrophages populations in adipose tissue

Author:

xiao xin-hua1ORCID,Liao zhe-zhen1,Wang ya-di1,Ran Li,Hu can,Gu Qian-qian,Peng Ting,Wu Liang-liang,Wang Yuan-Yuan,Qi xiao-yan,Zhu Li-Yong,Mai Yun-ni,Wang Qi-Yu,Yang Jing,Liu Jianghua

Affiliation:

1. The First Affiliated Hospital of University of South China

Abstract

Abstract Adipose tissues macrophages (ATMs) serve as a critical effector in the mediating occurrence of metabolic inflammation to impact whole-body insulin sensitivity in obesity. Discovering the key adipokines mediating crosstalk of adipocytes-macrophages and understanding the molecular mechanism of ATMs polarization and function have become hot topic issues in the immunometabolism fields. Zinc-α2-glycoprotein (ZAG) as a anti-inflammatory adipokines plays important roles in obesity-related metabolic diseases. We attempt to explore the precise role of adipose ZAG in metabolic inflammation and obesity-associated insulin resistance. Here we showed that Omental ZAG was positively associated with insulin sensitivity and M2 macrophages markers. ZAG-specific ablation in adipocyte aggravated insulin resistance and adipose tissues inflammation as evidenced by enhanced M1 macrophages proportion and inhibited AKT signaling pathway in mice fed with a high-fat diet. Exogenous ZAG inhibits PA-induced M1 macrophage polarization via β3-AR/PKA/STAT3 signaling in RAW264.7 macrophages.These findings suggest that adipocyte ZAG maintain insulin sensitivity via the cross talk with adipose-resident macrophages.

Publisher

Research Square Platform LLC

Reference46 articles.

1. Epidemiology and determinants of obesity in China;Pan XF;Lancet Diabetes Endocrinol,2021

2. Bizzotto, R., Trico, D., Natali, A., Gastaldelli, A., Muscelli, E., De Fronzo, R.A... New insights on the interactions between insulin clearance and the main glucose homeostasis mechanisms. Diabetes Care, et al.: ;doi.10.2337/dc21-0545. (2021)

3. Pharmacological targets of metabolism in disease: Opportunities from macrophages;Castegna A;Pharmacol. Ther.,2020

4. Macrophage-Targeted Therapeutics for Metabolic Disease;Peterson KR;Trends Pharmacol. Sci.,2018

5. Adipose tissue macrophages: Unique polarization and bioenergetics in obesity;Caslin HL;Immunol. Rev.,2020

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