Affiliation:
1. Public Health Clinical Center of Chengdu
2. Chengdu first people's hospital
3. Nanchong Central Hospital
4. Chengdu Women's and Children's Central Hospital
Abstract
Abstract
Objective
To systematically evaluate several factors of human papillomavirus (HPV) persistent infection following conization in patients with cervical intraepithelial neoplasia (CIN).
Methods
PubMed, EMBASE and Cochrane library were retrieved from January 1, 1998 to September 10, 2021. Random-effects models for meta-analyses was used and pooled relative risks with 95% confidence intervals was reported. Literature screening, data extraction and assessment of the risk of bias in the included studies were conducted independently by two researchers. Data-analysis was performed with Stata software, version 12.0.
Results
A total of 28 studies were enrolled finally in this study. Meta-analysis revealed that surgical margin and residual disease were correlated positively with the persistent HPV infection after conization. Compared with patients infected with other types of HPV, CIN patients with HPV 16 have higher persistent infection rate (OR = 1.967, 95% CI (1.232–3.140), P < 0.05).
Conclusions
CIN patients with postmenopausal, surgical margin and residual lesions positive, and HPV 16 are prone to persistent HPV infection after conization.
Publisher
Research Square Platform LLC