Preclinical study of Therapeutic application of Sertoli Cells transplantation for treatment of Neurodegenerative Diseases: A Systematic Review

Abstract

Abstract Progressive loss of neuronal function, brain atrophy, and abnormal protein deposition are the hallmarks of neurodegenerative diseases (NDs). NDs affect various parts of the brain and have various etiologies. Despite massive attempts to discover treatments for NDs during the past decades, there is still a need for effective therapeutic agents. Sertoli Cells (SCs), whether transplanted as allogeneic or xenogeneic cells, could offer a feasible opportunity for improving graft persistence by secreting immunomodulatory and trophic substances which shield replaced cells and tissues from the immune system. To date, there is no coherent information about the neuroprotective effects of SCs transplantation on NDs. Hence, this review tried to evaluate and report coherent information on the neuroprotective effects of these cells on NDs in preclinical settings. In this systematic review, the databases including, Scopus, PubMed, and ISI WEB of science were considered as a motor engine to search and get the relevant scientific articles and full text published between 2000 to 2022. Our search revealed 9 related articles on the effectiveness of SCs transplantation on NDs. Here, most of the evidence shows that SCs transplantation has promising effects on improving the symptoms of neurological diseases in rats. most of these relevant studies emphasize that many standardized preclinical trials should be conducted to provide reliable statistical evidence to confirm the application of SCs transplantation and the improvement of symptoms of neurodegenerative diseases.