Abstract
Objective: To investigatethe management status of hemophilia A patients in Fujian, Guangxi and Yunnan provinces in South China and their gaps with the national data. To explore which plays a more important role in hemophilia treatment, economical development or medical technology?
Methods: The data of hemophilia A patients registered in Fujian, Guangxi and Yunnan provinces were analyzed, and their diagnosis and treatment were studied and compared with the published national data.
Results: 542 hemophilia A cases were registered in Fujian, including mild ones 6.3%, moderate 73.2%, severe 12.6% and unknown 7.9%; 295 cases in Guangxi, mild 4.7%, moderate 22.7%, severe 30.5% and unknown 42.1%; 162 cases in Yunnan, mild 7.4%, moderate 45.1%, severe 42.6% and unknown 4.9%. The proportion of patients with severe hemophilia A in Fujian was significantly lower than that in Guangxi, Yunnan and national data (P < 0.05). Approximately29.2% had a delayed diagnosis in Guangxi (24.1% in Yunnan, 4.1% in Fujian, national data: 28.8%; P=0.000). The rate of delayed treatment is 17.3% in Guangxi, 4.9% in Yunnan,1.5% in Fujian and 39.2% in national data. The rate of joint deformity is 67.9% in Yunnan, 40.4% in Guangxi, 36% in national data and 17.0% in Fujian. The prophylactic treatmentrates in Guangxi and Yunnan were 16.9% and 27.2% respectively, which were statistically significant compared with the national rate (16.2%).
Conclusion: Diagnosis and treatment status of hemophilia A in the three southern provinces of China are significantly different from the national data. In hemophilia treatment, economical development plays a more important role.At similar economic levels, medical technology will cause a gap in the level of hemophilia treatment.