In vivo anti-tumor effect of Atractylodes macrocephala Koidz and Zingiber prescriptions combined with paclitaxel in mice bearing ID8 ovarian carcinoma

Abstract

Abstract Background Paclitaxel is the first-line chemotherapy drug for ovarian carcinoma, and chemotherapy resistance to paclitaxel is closely related to the recurrence and poor prognosis of ovarian carcinoma. Our previous in vitro experiments demonstrate that Atractylenolide-I and 6-shogaol can be used as natural antagonists to target and block the TLR4 /MyD88-mediated paclitaxel resistance pathway. Purpose The majority of traditional herbal preparations are water-based prescriptionss, which results in a low yield of pharmacologically active lipid-soluble components. This preparation follows the decoction method of classic prescriptions (half decoction in wine and water), and maked the Atractylodes macrocephala Koidz and Ginger alcohol /aqueous extracts. Methods The effective contents of Atractylenolide-I and 6-shogaol in This preparation were determined by HPLC with main active components. Results This preparation were effective in inhibiting the growth of paclitaxel-treated tumors, accompanied by increased apoptosis and improved survival. In combination with paclitaxel, Atractylodes macrocephala Koidz and Zingiber alcohol /aqueous extracts had better anticancer efficacy than Atractylodes-I and 6-shogaol. Furthermore, no hepatic or kidney toxicity could be observed. Conclusion Atractylodes macrocephala Koidz and Zingiber alcohol /aqueous extracts may provide a clinically useful natural remedy for the treatment of cancer with active components that promote paclitaxel sensitization.