The effects of aerobic exercises compared to conventional chest physiotherapy on pulmonary function, functional capacity, sputum culture, and quality of life in children and adolescents with cystic fibrosis: a study protocol for randomized controlled trial study

Abstract

Abstract Background Cystic Fibrosis (CF) is an autosomal recessive disorder caused by abnormal function of the chloride ion channel, and characterized by pancreatic insufficiency, and chronic endobronchial airway infection. Pulmonary dysfunction is very common and could lead to a reduction in the quality of life. Airway Clearance Techniques (ACT) and physical exercises are introduced as one of the main components of treatment. Therefore, it will be of interest to examine the effect of aerobic exercises compared to Conventional Physiotherapy (CPT) on pulmonary function, exercise capacity, functional capacity, sputum culture, and quality of life in patients with CF. Methods Thirty Patients with CF will participate in a double-blind parallel controlled trial containing 18 sessions of treatment. Group A consists of CPT and placebo aerobic exercise, and group B includes aerobic exercise and placebo CPT. Pulmonary function, functional capacity, sputum culture, and quality of life will be evaluated with a spirometry test, 6-minute walk test (6MWT), sputum culture test, and the Cystic Fibrosis Questionnaire-Revised (CFQ-R), respectively before and after the intervention. Discussion We will evaluate and compare the effectiveness of aerobic exercises and conventional chest physiotherapy on pulmonary function, functional capacity, sputum culture, and quality of life. Comparing these two treatment patterns can contribute to a better understanding of the effectiveness. Therefore, if there is a significant difference between two treatments, the superior treatment will be prioritized clinically. Trial registration: This trial is registered at https://www.irct.ir, under trial number IRCT20210505051181N5, approved at 2/19/2023.