Network Pharmacology-Oriented Identification of Key Proteins and Signaling Pathways of breast cancer

Abstract

Moringa oleifera is a perennial angiosperm plant widely used in Asia in the treatment of various diseases, including cancer. In the study, we investigated the molecular mechanism of the chemical constituents of moringa against targets in breast cancer using network pharmacology and virtual screening. Network pharmacology is a systematic approach to identifying potential targets and pathway networks associated with disease pathology. The steps in network pharmacology include text mining, in which we retrieve multiple genes and proteins associated with disease from different bioinformatics databases. Then enrichment analysis to identify the top pathways and associated targets with those pathways in the disease pathway and the construction of the network and its analysis using software and web-based tools. The obtained targets were further screened by molecular docking for their binding characteristics. In the study, moringa extract was studied for antimitotic activity against meristematic cells.