Molecular characterization of head and neck infection causing bacterial communities using 16S rRNA in eastern Indian population

Abstract

Abstract Head and neck infections (HNI) are dangerous illnesses caused by a variety of bacterial species. Due to either incorrect diagnosis or excessive antibiotic usage, multidrug resistance (MDR) poses a problem on a global scale. We aimed this study to identify and compare their relationship with eastern Indian MDR bacteria.We collected 264 HNI clinical samples (2020–2022) from the eastern Indian state of Odisha to investigate the bacterial isolates associated with HNI, as well as the characterization was performed with their drug susceptibility and assessment of their diversity by comparison with worldwide bacterial isolates. There are 218 positive bacterial samples. Using the 16S rRNA gene, we performed molecular characterization and phylogenetic analysis on 25 multidrug-resistant bacteria. According to population genetic factors, the haplotype (Hd) and nucleotide diversity (π) ranged from 0.558 to 0.828 and 0.03236 to 0.28428.The prevalence of these neglected pathogens within this rarely focused geographical area and the transboundary potential to find better therapeutic approaches can be possible through this study.