Design of an electrospun polyvinyl alcohol (PVA)/chitosan/curcumin based- wound dressing containing titania nanotubes (TNT)

Abstract

Abstract Burn wounds are one of the most significant causes of morbidity around the world. Burn wound healing and skin tissue regeneration still have serious and considerable challenges. This study applies the electrospinning method to make PVA-chitosan-curcumin wound dressing containing titania nanotubes with 0.5, 1.5, and 3 wt%, following that their physicochemical properties were investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and mechanical test. Then, the in vivo effectiveness of the designed wound dressing in the wound healing process in the Wistar rat model was evaluated for two weeks. The most important result of applying the TiO2 nanotube was the improved regeneration of damaged tissues with an appreciable decline in scar formation, skin color anomalies, and accelerated wound healing and contraction.