Effectiveness and security analysis of 577nm subthreshold micropulse laser in the treatment of aCSC with full coverage of serous detachment area

Abstract

Abstract Objective 5X5 matrix thick method of 577 nm substituting micropulsive lasers (SML) was used to treat acute central serous chorioretinopathy (aCSC) with leakage essence within 500µm of the fovea to perform full coverage of the serous detachment area. The effectiveness and safety of this method was evaluated. Methods Patients were enrolled and treated with 577 nm SML by the same physicianwith unified operation procedure. 577nm SML was applied to aCSC to treat subretinal fluid (SRF) including PED area without full coverage of the spot interval. These are contrased that the best corrected visual acuity (BCVA), central retina thickness (CRT), choroidal vascular index (CVI). SPSS 18.0 was used to perform repeated measures analysis of variance on LogMAR BCVA and CRT. Paired t-test analysis for CVI was performed with SPSS 18.0.and Optical coherence tomography (OCT) was used to observe the anatomical structure and retinal destruction . Results 23 patients with 24 eyes were collected and followed up. The results showed that LogMAR BCVA and CRT of 1 week, 1 month, and 3 months after treatment, compared with baseline had statistically significant(p < 0.01);1w after treatment compared with 1m after treatment, which has statistically significant༈p < 0.01༉༛1m, 3m after treatment compared with p > 0.05, which was not statistically significant. In addition, baseline CVI compared with 3 months after treatment, which was statistically significant (P < 0.05). There was no retinal neovascularization (CNV), and only 3 eyeballs had granular hyperreflective deposition under the neuroepithelial layer, but CRT is normal and no subretinal fluid (SRF), macular edem. Conclusion 577 nm SML is effective in the treatment of aCSC with less side effects. It is the first choice for aCSC within 500um from the fovea. On this basis, it is safe to fully cover the serous detachment region, and it can accelerate the soaking up of serous liquid under the neuroepithelial layer. It is a good choice for aCSC with insignificant leakage points or multiple leakage points.