Coarctation of Aorta Computational Fluid Dynamics Analysis after Three-Dimensional Reconstruction and Clinical Application

Abstract

Abstract Objective: To investigate the clinical significance of Computational Fluid analysis in diagnosing and treating coarctation of aorta after three-dimensional reconstruction of CTA. Methods: The clinical data and imaging data of 40 children with coarctation of aorta and 24 normal children were retrospectively analyzed and summarized, and combined with statistical means and computational fluid dynamics and explored the potential of clinical application. Results: (1) Computational fluid pressure difference and color Doppler pressure difference analysis were performed in 40 children with coarctation of aortic arch and 24 normal children.There was no significant difference (P > 0.05) in fluid pressure between the 40 patients with coarctation group was 63.1 ± 5.1 mmHg compared with its preoperative color ultrasound pressure difference (64.1 ± 5.2 mmHg), whereas there was a significant difference (P <0.01 ) in fluid pressure between the 40 patients with coarctation of aorta and 24 patients with normal aortic arch was (4.4 ± 1.0) mmHg ;(2) After three-dimensional reconstruction, computational fluid dynamics analysis was performed to analyze the changes in pressure gradient along the aortic path, mainly in the constricted segment, and in-depth discussion and analysis were conducted. The measured pressure drop at the largest constricted segment in the constricted group was greater than 35 mmhg, while the corresponding pressure drop in the normal group children was less than 10 mmhg. The fluid vector graph showed a sharp decrease in pressure in the constricted segment, which was significantly different from the normal group. Conclusion: Computational fluid dynamics for the diagnosis and treatment of coarctation of aorta is consistent with clinical imaging analysis methods; As a new tool for the diagnosis of coarctation of aorta , Computational fluid dynamics has the same clinical benefits, but also has many advantages that imaging does not have. Its application range is broader. Although the current sample size is not sufficient to develop new diagnostic standards, three-dimensional reconstruction of fluid dynamics analysis can provide a lower cost, less patient pressure, less uncertainty, and more accurate and intuitive assessment of the overall pressure change process of the aortic arch, It has a more comprehensive and systematic guiding significance for the diagnosis and treatment of children with coarctation of aorta.