Abstract
Background:With the increase of the elderly population, the problem of senile frailty is becoming more and more serious. The research on frailty is still in the initial stage, and the diagnosis and intervention mechanism of frailty are still unclear. This study investigated the effects of Vitamin D and Insulin-like growth factor-1 on frailty, in order to further provide more accurate interventions for improving frailty.
Purpose:To investigate the frailty characteristics of elderly residents in Mengyang community, Chengdu City, Sichuan Province. To explore the correlation between serological index and human body composition test index; correlation between body composition test index and frailty; to explore the effects of both on frailty.
Method:From July to August 2023, 433 residents in Mengyang community of Chengdu City, Sichuan Province were selected. According to the diagnostic criteria of Fried Evaluation Form, they were divided into non-frailty, pre-frailty and frailty stages. For elderly comprehensive evaluation, including the human body composition test index and physical function test project, and blood tests for Vitamin D and Insulin-like growth factor-1.
Result: Among the 433 elderly patients, 201 were males and 232 were females, aged 60 to 99 years. The median age was 69.27±4.23 in the non- frailty group (99 cases), 71.07±4.687 in the pre-frailty group (173 cases) and 75.4±7.407 in the frailty group (161 cases). The muscle content and physical function indexes of each part of the body composition decreased gradually with the increase of the degree of weakness, and P<0.05. Vitamin D and insulin-like growth factor-1 decreased gradually with the increase of frailty degree, but P > 0.05. Vitamin D and insulin-like growth factor-1 had a certain correlation with the muscle content in all parts of the body, and the muscle content in all parts of the body had a certain correlation with the indexes of body function (P<0.05).
Conclusion: Vitamin D and Insulin-like growth factor-1 are significantly positively correlated with the muscle content of each part of the body, and there is a significant correlation between the muscle content of each part and the body function. With the increase of frailty, the functional indicators of the elderly(including muscle content in various parts、Vitamin D and Insulin-like growth factor-1 levels) decreased, while the physical functional indicators also decreased with the increase of frailty.