The Contemporary Management and Coronary Angioplasty Outcomes in Young Patients with ST- Elevation Myocardial Infarction (STEMI) age < 40 years old: The Insight from Nation-wide Registry

Author:

Porapakkham Pornwalee1,Porapakkham Pramote1,Srimahach Suphot2,Limpijankit Thosaphol3,Kiatchoosakun Songsak4,Chandavimol Mann3,Kanoksilp Anek1,Chantadansuwan Thamarath1,Thakkinstian Ammarin3,Sansanayudh Nakarin5

Affiliation:

1. Central Chest Institute of Thailand

2. King Chulalongkorn Memorial Hospital

3. Mahidol University

4. Khonkaen University

5. Phramongkutklao Hospital

Abstract

Abstract Background Cardiovascular disease (CVD) remains one of the major causes of death around the world in which ST elevation MI (STEMI) is in the lead. Although the mortality rate from STEMI seems to decline, this result might not be demonstrated in young adults who basically have different baseline characteristics and outcomes compared with older patients. Methods Data of the STEMI patients aged 18 years or older who underwent PCI during May 2018 to August 2019 from Thai PCI Registry, a prospective, multi-center, nationwide study, was included and aimed to investigate the predisposing factors and short-term outcomes of patients aged < 40 years compared with age 41–60, and > 61 years. Results Data of 5,479 STEMI patients were collected. The patients’ mean age was 62.6 (SD = 12.6) years, and 73.6% were males. There were 204, 2,154, and 3,121 patients in the youngest, middle, and oldest groups. The young patients were mainly male gender (89.2% vs 82.4% and 66.6%; p < 0.001), were current smokers (70.6%, 57.7%, 34.1%; p < 0.001), had BMI ≥ 25 kg/m2 more frequently (60.8%, 44.1%, 26.1%; p < 0.001), and had greater family history of premature CAD (6.9%, 7.2%, 2.9%; p < 0.001). The diseased vessel in the young STEMI patients was more often single vessel disease with the highest percentage of proximal LAD stenosis involvement. Interestingly, there were trends of higher events of cardioversion/defibrillation, procedural failure, procedural complications, and prolonged median hospital stay in both youngest and oldest groups compared to the middle-aged group. In-hospital death was found in 3.4% in the youngest group compared to 3.3% in the middle-aged patients and 9.2% in the older patients (p < 0.001). Conclusions STEMI in young patients is not uncommon nowadays. Although the mortality rate of PCI in real-world practice was low, young patients had a trend of having higher procedural failure and complications of PCI when compared with middle-aged group. Their major modifiable factors were smoking and obesity.; Therefore, encouraging young people to quit smoking and control weight might be essential to prevent STEMI in the young.

Publisher

Research Square Platform LLC

Reference40 articles.

1. Updates on acute coronary syndrome: a review;Eisen A;JAMA Cardiol,2016

2. Trends in acute myocardial infarction in young patients and differences by sex and race, 2001 to 2010;Gupta A;J Am Coll Cardiol,2014

3. Global and regional patterns in cardiovascular mortality from 1990 to 2013;Roth GA;Circulation,2015

4. Twenty year trends and sex differences in young adults hospitalized with acute myocardial infarction;Arora S;Circulation,2019

5. Treatment and outcomes of patients under 40 years of age with acute myocardial infarction in Poland in 2009–2013: an analysis from the PL-ACS registry;Trzeciak P;Pol Arch Intern Med,2017

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3