Preoperative eGFR can predict short-term death and hospital stay in patients with acute aortic dissection

Abstract

Abstract Background Acute aortic dissection (AAD) is a life-threatening disease and requires urgent treatment. We assessed the relationship between preoperative eGFR in patients with acute aortic dissection and short-term death and hospital stay. Methods Patients were categorized based on the eGFR. Logistic regression analysis was performed to assess whether the eGFR was a risk factor for 7-day,28-day, and 60-day mortality. The Kaplan-Meier survival curve was used to analyze the relationship between the eGFR and the 7-day, 28-day, and 60-day survival rates in AAD. Results A total of 122 patients with AAD were enrolled. There were 94 males (77%), with a mean age of 57.75 ± 13.52 years. The total mortality amounted to 23/122 patients (18.9%): 18 (14.8%) patients died within 7 days and 23 patients died within 60 days. The multiple logistic regression analysis showed eGFR [HR = 0.284, 95% CI (0.103-0781), P = 0.015] and MBP [HR = 0.165, 95% CI (0.051-0533), P = 0.003] were independent risk factors for 60-day mortality. The correlation analysis showed that the levels of eGFR are inversely proportional to the length of hospital stay (R2 = 0.209, P = 0.039). The Cox regression analysis showed that eGFR [HR = 0.264, 95% CI (0.086–0.809), P = 0.020], BMI [HR = 3.178, 95% CI (1.095–9.225), P = 0.033], treatment methods [HR = 49.776, 95% CI (5.915–418.880), P < 0.001] are associated with the length of hospital stay. Conclusions Lower preoperative eGFR is associated with higher 7-days,28-days, and 60-day death and the length of hospital stay in AAD patients. By improving renal perfusion and maintaining the stability of eGFR, the prognosis of these patients may be enhanced.