Abstract
The maximum coagulation velocity (|Min1|), a parameter of the clot waveform analysis (CWA) based on activated partial thromboplastin time (APTT), is the peak coagulation velocity of thrombin on fibrinogen. This comprehensive index reflects the effectiveness of patients' hemostatic response to injury. Our study aimed to investigate changes in |Min1| based on different coagulation states and compare them with the traditional coagulation index APTT. We examined the characteristics of |Min1| in 655 Chinese patients. Healthy patients from the check-up center were included as healthy controls (n = 79, including 34 women serving as a control group of non-pregnant women and 69 subjects serving as healthy controls of patients with hypercoagulability). The hypercoagulability groups were the thrombosis group (n = 50), fracture group (n = 43), trauma group (n = 36), infection group (n = 74), tumor group (n = 106), early pregnancy group (n = 135), late pregnancy group (n = 85), and a low coagulation group (n = 49) on long-term warfarin treatment with considerably above average international standard ratio (ISI) times. Our study revealed that |Min1| in each hypercoagulability group was significantly higher than in the corresponding control group, with a statistically significant difference (P < 0.05). However, APTT in the infection and trauma groups did not show statistically significant differences compared to the control group (P > 0.05). The variation range of |Min1| in all hypercoagulability groups was considerably more extensive than that of APTT compared to the corresponding control group, and the area under the ROC curve (AUC) for |Min1| was substantially more significant than that for APTT, particularly in the infection and late pregnancy groups. Compared to the early pregnancy group, |Min1| in the late pregnancy group was significantly higher (P < 0.05). However, these two groups had no statistically significant difference in APTT (P > 0.05). In the low coagulation group, the hemostatic ability represented by |Min1| may not decline with the prolongation of APTT within a specific range, but further studies are needed to confirm this finding.