Prospective analysis of pre and postoperative laboratory parameters associated with thrombosis in patients with ovarian cancer

Abstract

Abstract Background Patients with ovarian cancer have a high risk of developing thrombosis. We aimed to investigate laboratory parameters associated with thrombosis including deep vein thrombosis (DVT) and pulmonary thromboembolism in patients treated for ovarian cancer.Methods We collected pre and post operative blood samples from 133 patients undergoing surgery for ovarian cancer at National Cancer Center, Korea between December 2021 and August 2022. The measured parameters were white blood cell (WBC) count, hemoglobin, platelets, monocytes, serum glucose, CA125, D-dimer, fibrinogen, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen degradation products (FDP), antithrombin III, protein C, protein S, plasminogen, plasminogen activator inhibitor 1 (PAI-1), homocysteine, N-terminal pro-brain natriuretic peptide (NT-proBNP), interleukin 6 (IL-6), thrombopoietin (TPO), soluble P-selectin and granulocyte stimulating factor (G-CSF). Body mass index (BMI) of patients were collected. Differences between patients who developed thrombosis and those without were compared with Wilcoxon rank-sum test and we analyzed the continuous variables using logistic regression.Results Twenty-one (15.8%) patients developed thrombosis ranging from 6 to 146 days (median 15 days) after surgery. FIGO stage, age and BMI were not significantly different among the two groups. Pre operative values of homocysteine (p = 0.033) and IL-6 (p = 0.043) were significantly increased and post operative aPTT (p = 0.022) was prolonged and plasminogen (p = 0.041) was decreased in patients with thrombosis.Conclusions Pre operative homocysteine, IL-6 and post operative aPTT, plasminogen were associated with thrombosis in ovarian cancer patients.