The “Rejuvenating Factor” - Platelet Factor 4 in Platelet Transfusion - Myth or Reality?

Abstract

Abstract Population in the world, is ageing. World Health Organization estimated an increase of 60years and more human, to 30% of the population, with a growing frequency of cognitive and cardiovascular disease. Recently, platelet Factor 4 (PF4) was presented as a pro-cognitive factor when administered to mice. This molecule is released by platelet in circulation and could be present in blood product destined to transfusion. We wondered if PF4 levels could be correlated to blood donor age or to the process of platelet concentrate (PC) preparation intended for transfusion? We observed higher levels of PF4 in elderly compared to younger donor PCs, while PC processing & storage did not alter PF4 expression.