Role of Mast Cell, Ki-67 and Bcl-2 in the Diagnosis of Mycosis Fungoides

Abstract

Abstract Diagnosis of early-stage MF, there are molecular studies that include Bcl-2 and ki-67, but there is no study showing that mast cells can be used both in the diagnosis of early-stage MF and in the etiopathogenesis of MF. In our study, we aimed to show that Ki-67, Bcl-2 and mast cell staining, which can be easily obtained in every laboratory, are helpful markers in the diagnosis of early-stage MF. Methods: A total of 81 cases, including 27 Mycosis Fungoides, 27 benign inflammatory dermatoses (psoriasis, lichen planus, eczema) and 27 patients without any disease, were included in the study retrospectively. Ki-67, Bcl-2 and mast cell counts were made under a light microscope with stained slides. Results: Mast cells were found to be significantly higher in cases of mycosis fungoides compared to cases of benign inflammatory dermatosis (p>0.001). In mycosis fungoides cases, ki-67, Bcl-2 and mast cells were significantly higher compared to the control group (p>0.001). In benign inflammatory dermatosis cases, ki-67 and Bcl-2 were found to be significantly higher than the control group (p>0.001). Conclusion: MF lesions are initially included in the differential diagnosis of many diseases including eczema, psoriasis, and lichen planus. In this case, histopathological examination is used in order to reach a clear diagnosis. Ki-67, Bcl-2 and mast cells were found significantly higher in MF patients compared to the control group. However, no difference was found between MF and benign inflammatory dermatoses in ki-67 and Bcl-2 staining.