Affiliation:
1. First Hospital of China Medical University
Abstract
Abstract
We aim to investigate the roles of succinate dehydrogenase complex subunit B (SDHB) in the pathogenesis of sarcopenia. We identified 1554 differentially expressed genes from 33824 background genes in sarcopenia versus non-sarcopenia control as well as SDHB-low group versus high group. The 1365 genes of the turquoise module were most strongly associated with sarcopenia and those with low SDHB expression, which were enriched in oxidative phosphorylation, thermogenesis, ribosome and tricarboxylic acid (TCA) cycle. The cross-talking pathways of SHDB in sarcopenia were determined, including oxidative phosphorylation, TCA cycle and thermogenesis. Low expressions of SDHB may be a potential pathogenic factor of sarcopenia, and may be related to oxidative phosphorylation, TCA cycle and thermogenesis.
Publisher
Research Square Platform LLC
Reference45 articles.
1. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment;Chen LK;J Am Med Dir Assoc,2020
2. Risk Factors for Sarcopenia in the Elderly with Type 2 Diabetes Mellitus and the Effect of Metformin;Chen F;J Diabetes Res,2020
3. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39(4),412–423 (2010).
4. Sarcopenia: revised European consensus on definition and diagnosis;Cruz-Jentoft AJ;Age Ageing,2019
5. Microphysiological system for studying contractile differences in young, active, and old, sedentary adult derived skeletal muscle cells;Giza S;Aging Cell,2022