Single-cell RNA sequencing applications in abdominal aortic aneurysm: A mini review

Abstract

Abstract In the past decade, advances in single-cell RNA sequencing (scRNA-seq) technology have revolutionized biomedical research, enabling the characterization and analysis of the transcriptomes of single cells with remarkable precision and throughput. Specifically, scRNA-seq has assisted in the identification of novel or rare cell types, the analysis of single-cell trajectory formation and stem or progenitor cell development, and the single-cell resolution comparison of healthy and disease-related tissues. The generation of cell atlases of the mammalian heart and blood vessels, as well as the elucidation of mechanisms involved in cardiovascular development and stem or progenitor cell differentiation, demonstrate the importance of these applications to the advancement of cardiovascular research over the past decade. This review examines the applications of scRNAseq in AAA research and discusses the molecular pathways of cardiovascular development and diseases uncovered by scRNA-seq analysis that could be implemented in clinical practice.