Transitions in metabolic syndrome and metabolic obesity status over time and risk of urologic cancer: A Prospective Cohort Study

Abstract

Abstract The association between metabolic syndrome (MetS) and metabolic obesity (MO) status at baseline, their dynamic changes and the risk of developing urologic cancer (UC) have not been reported.This paper studied 97,897 observation subjects who were free of cancers at baseline (2006−2007). Transitions in MetS and MO status from 2006–2007 to 2008–2009 were considered. The hazard ratios (HRs) and 95% confidence intervals (CIs) for UC were assessed by multifactorial Cox proportional risk regression models. During a median follow-up of 14.02 years, 554 cases of UC were diagnosed. MetS and metabolically unhealthy obesity (MUO) increased the risk of developing UC at baseline. Transitions of MetS to MetS, MUO to MUO and even MUO to metabolically healthy obesity (MHO) over time significantly increased the risk of UC development. Thus, our study provides useful insights into preventing UC.