Non-interventional weight changes are associated with alterations in uric acid levels

Abstract

Abstract Background uric acid is an emerging cardiovascular risk factor. Obesity is associated with higher serum UA. Objective we aimed to assess whether non-interventional weight changes affect serum UA. Design a retrospective analysis of subjects referred to annual medical screening. Body mass index (BMI) and uric acid were measured annually. Participants 19,193 patients were divided to five groups according to the change in BMI between visits (large reduction, moderate reduction, unchanged, moderate increase, and large increase). Main Measure the primary outcome was the change in uric acid levels between visits. Key Results uric acid levels were progressively lower or higher as BMI decreased or increased, respectively. The proportion of patients with at least 10% rise in uric acid progressively increased with the relative increase in BMI, while the proportion of patients with at least 10% decrease in uric acid decreased with the relative increase in BMI. Conclusions even modest non interventional weight changes are associated with serum uric acid.