Exploring the Correlation between HAdV Infection and Respiratory Tract Infection Symptoms: A Study in Nanning, China

Abstract

Abstract Background Human adenoviruses (HAdV) can cause various diseases, but there is limited information about the genotype diversity and epidemiology of HAdV associated with respiratory tract infections (RTIs) in Nanning.Methods From Jun 2019 to December 2021, throat swab, nasal swab, or nasopharyngeal swab samples were collected from hospitalized patients with RTIs, and Epidemiological data were analyzed using statistical software. HAdV were detected using a qPCR assay targeting a highly conserved 132-bp gene region of the HAdV hexon, and phylogenetic analysis was performed on the 875-bp hexon gene fragment.Results The age and sex distribution of HAdV-positive patients showed significant differences (P = 0.014 and P = 0.025, respectively). The majority of HAdV-positive patients were in the 0–6 age group (67.89%). The HAdV detection rate showed the highest prevalence in spring and autumn, peaking in February. In addition, a total of 37 HAdV-positive samples with 875-bp fragments were successfully genotyped and found to be circulating in Nanning from 2019 to 2021 with HAdV species B, C, and E.Conclusions HAdV prevalence is associated with age and season, with HAdV-B, HAdV-C, and HAdV-E co-circulating among hospitalized patients with RTIs in Nanning. The most frequent genotypes were HAdV-C1, HAdV-C6, and HAdV-E4.