Evaluation of survivability predictors in acute kidney injury-affected dogs managed with continuous renal replacement therapy

Abstract

AbstractSeveral survivability predictors have been identified in acute kidney injury (AKI) affected humans managed with continuous renal replacement therapy (CRRT). The aim of this study was to evaluate various blood and urine parameters as survivability predictors in AKI affected dogs managed with CRRT. Twenty dogs that presented with AKI to a veterinary hospital were managed with CRRT. Physical examination, urinalysis, arterial/venous blood gas analysis, and ELISA for analysis of Kidney Injury Molecule-1 (KIM-1) and Cystatin-C (Cys-C) were performed on the first day of presentation (Pre-CRRT). Survivability evaluated on day 21 post-CRRT indicated 12 survivors and 8 non-survivors. Pre-CRRT parameters were compared between survivors and non-survivors using independent t-tests. Of the various parameters analyzed, KIM-1 concentrations and anion gap (AG) were significantly different between survivors and non-survivors. Other parameters such as APACHE III score, Cys-C, renal failure index (RFI), and fractional excretion of sodium (FENa) were not significantly different between survivors and non-survivors. Results of this study suggest that KIM-1 and AG could be employed as survivability predictors in AKI affected dogs managed with CRRT.