Empagliflozin-Associated Pancreatitis in the Setting of Hyperglycemic Hyperosmolar Syndrome

Author:

Borrelli Jenna Catherine1,Cioffi Martine Anne1,Martini Nora2ORCID,Samarneh Majed Mark3

Affiliation:

1. LECOM: Lake Erie College of Osteopathic Medicine

2. St. John Riverside Hospital

3. St. John's Riverside Hospital

Abstract

Abstract Acute pancreatitis is the leading cause of gastrointestinal hospital admissions in the United States [1]. While there are variety of presentations, the majority to not require stay in the intensive care unit. Medication side effect is one large cause of pancreatitis. More recently diabetic agents have been linked to pancreatitis. Here we describe a case of pancreatitis caused by a SGLT-2 Inhibitor, Empagliflozin, and the acceleration into hyperosmolar hypoglycemic syndrome and ICU admission. We hope to provide more information for clinicians detailing the link and outlining the management in cases such as this which do significantly increase inpatient morbidity and mortality.

Publisher

Research Square Platform LLC

Reference8 articles.

1. (n.d.).;Vege SS;UpToDate Retrieved February,2023

2. Nationwide Trends in Acute and Chronic Pancreatitis Among Privately Insured Children and Non-Elderly Adults in the United States, 2007–2014;Sellers ZM;Gastroenterology,2018

3. Critical care management of severe acute pancreatitis;Tesoriero R,2016

4. Drug-induced acute pancreatitis: a review;Jones MR;Ochsner J

5. Risks vs Benefits for SGLT2 Inhibitor Medications;Pittampalli S;Fed Pract,2018

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