Immuno-modulatory Effects of a Herbo-mineral Ayurvedic Formulation in Experimental Models

Abstract

Abstract Ayurveda, an ancient Indian system of medicine, encapsulates comprehensive principles and formulations for disease prevention and treatment. A herbo-mineral Ayurvedic formulation, IMMBO, comprising Mandoor Bhasma and eighteen herbs has shown promising results in treating Allergic Rhinitis. The said efficacy was recently reinstated by a randomized controlled clinical trial conducted at a reputed hospital and IMMBO significantly reduced the IgE levels and Total nasal symptom scores in treated patients. This article discusses the findings of a series of experimental studies conducted to explore the immuno-modulatory potential of IMMBO. The studies reveal the immunomodulatory effects of IMMBO, evidenced by its effectiveness in reinstating neutrophil activation, stimulating cellular and humoral immunity, and counteracting immunosuppression at the molecular level. The modulation of key signalling molecules, including TNF-α, IFN-γ, IL-1β, ERK, PI3K, and NF-κB, showcases the formulation’s multifaceted impact. Additionally, its ability to block histamine release suggests potential in controlling allergic states, positioning it as a promising therapeutic candidate for immune-related disorders. However, the precise mode of action remains elusive, warranting further in-depth pharmacological studies. This research substantiates the ancient Ayurvedic wisdom using modern scientific parameters, endorsing IMMBO's potential as an immune-modulatory agent.