Identification of Potential Lead Compound as Promising SARS Covid-2 Inhibitors Using Structure Based Drug Design-Reference-Cited by-同舟云学术

Identification of Potential Lead Compound as Promising SARS Covid-2 Inhibitors Using Structure Based Drug Design

Published:2023-05-02 Issue: Volume: Page:
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Author:

KR Kavya¹,V Ajeesh²

Affiliation:

1. Al Shifa College of Pharmacy

2. Ikon Pharmacy College

Abstract

Abstract SARS-CoV−2 has surpassed other coronaviruses in transmission rate, reproduction number, and global deaths, but its case fatality rate remains low. The receptor-binding domain (RBD) of SARS-CoV−2 interacts to human angiotensin-converting enzyme 2 (ACE2) to promote fusion between the S protein and the human cell membrane, boosting the infectivity of the virus. The virtual screening of plant flavonoids offers fresh insight for the treatment of covid, while the majority of allopathic medicines have failed to totally recover. In this study, we sought to develop an alkaloid that can interact competitively with the catalytic regions of SARS COV 2 binding proteins, TMPRSS2 and inhibit the growth of the covid virus.

Publisher

Research Square Platform LLC

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