Affiliation:
1. First Affiliated Hospital of Harbin Medical University
2. Wuxi People's Hospital Attached to Nanjing Medical University
Abstract
AbstractBackgroundOvarian cancer (OV) is characteristic of high incidence rate and fatality rate in the malignant tumors of female reproductive system. Researches on pathogenesis and therapeutic targets for OV need to be continued. This study mainly analyzed the immune-related pathogenesis and discovered the key immunotherapy targets for OV.MethodsWGCNA was used for excavating hub gene modules and hub genes related to immunity of OV. Enrichment Analysis were aimed to analyze the related pathways of hub gene modules. Biological experiments were used for exploring the effect of hub genes on SKOV3 cells.ResultsWe identified two hub gene modules related to the immunoscore of OV and found that these genes in the modules were related to the extracellular matrix and viral infections. At the same time, we also discovered six hub genes related to the immunity of OV. Among them, KIF26B and CREB3L1 can affect the proliferation, migration and invasion of SKOV3 cells by the Wnt/β-catenin pathway.ConclusionsThe local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.
Publisher
Research Square Platform LLC
Reference45 articles.
1. International Agency for Research on Cancer. https://www.iarc.fr/faq/latest-global-cancer-data-2020-qa/. Accessed 2 Jan, 2021.
2. Treatment of epithelial ovarian cancer;Kuroki L;BMJ,2020
3. Delivery technologies for cancer immunotherapy;Riley RS;Nat Rev Drug Discov,2019
4. Immunotherapy in ovarian cancer;Odunsi K;Ann Oncol,2017
5. Immune Characterization of Ovarian Cancer Reveals New Cell Subtypes With Different Prognoses, Immune Risks, and Molecular Mechanisms;Cong S;Front Cell Dev Biol,2020
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献