Affiliation:
1. Guru Nanak Dev University
Abstract
Abstract
Fat mass and obesity associated (FTO) gene belongs to the non-heme Fe (II) and 2 oxoglutarate dependent dioxygenase superfamily. FTO gene has been evolved as a potent genetic risk factor for the development of obesity. To establish the potential association between FTO rs17817449 T > G and rs9939609 T > A polymorphisms and obesity risk in north Indian Punjabi population, a total of 333 obese and 338 non-obese control subjects were randomly selected. Both the FTO gene polymorphisms rs17817449 (TT vs GG: odds ratio (OR), 2.30; 95% confidence interval (CI), 1.39–3.79) and rs9939609 (TT vs AA: odds ratio (OR), 2.78; 95% confidence interval (CI), 1.37–5.64) were significantly associated with obesity and conferred 2-fold and 3-fold risk toward the development of obesity respectively. Logistic regression analysis determined the significant association under the recessive genetic model (OR = 2.29; 95%CI: 1.47–3.57) and (OR = 5.25; 95%CI: 2.68–10.28) respectively for rs17817449 and rs9939609 thereby confirming the major role of environmental and anthropometric factors in this population. Haplotype analysis revealed that TA haplotype conferred 4-fold risk towards obesity (p = 0.0001). The rs17817449G allele and the obesity associated covariates accounted for 55%, 49%, 42%, 34%, 31% and 22% variability in body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride (TG) respectively. For rs9939609A allele contributed 98%, 82%, 54%, 59%, 71% and 84% variability in BMI, WC, WHtR, SBP, DBP, TG respectively in obese individuals. Therefore, the present study suggested that both the polymorphisms of FTO gene (rs17817449 T > G and rs9939609 T > A) are relevant markers of obesity in the north Indian Punjabi population and both plays an important role in an individual’s predisposition towards obesity.
Publisher
Research Square Platform LLC
Reference59 articles.
1. Eating behaviours and food cravings; influence of age, sex, BMI and FTO genotype;Abdella HM;Nutrients,2019
2. Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents;Abdelmajed SS;Genes & diseases,2017
3. Association of FTO common variant (rs9939609) with body fat in Turkish individuals;Ağagündüz D;Lipids health dis,2019
4. Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children;Almeida SM;Endocrine,2018
5. Association of FTO rs9939609 with obesity in the Kuwaiti population: a Public Health Concern?;Al-Serri A;Medical Principles and Practice,2018